|
Jue Chen
Associate Professor
Ph.D., Harvard, 1998
|
Address:
Dept of Biological Sciences
Purdue University
915 W. State St.
West Lafayette IN
47904-2054 |
Phone:
765-496-3113
Email:
chenjue AT purdue.edu
|
Research Areas:
X-ray crystallography and protein chemistry; ABC
transporters and membrane fusion proteins |
|
Research Description
Our lab is interested in structure-function
studies of ATP-binding-cassette (ABC) transporters, also known as
traffic ATPases. ABC transporters are the most common protein
machineries that pump a variety of substrates across biological
membranes. As some ABC proteins are related to severe diseases
such as cancer, cystic fibrosis, and macular degeneration, insights of
the transport mechanism will have significant impact in biology and
medicine. We use both biochemical methods and X-ray crystallography to
elucidate the mechanism of the bacteria maltose transporter. We
also study the class II viral membrane fusion mechanism. Recent
structural and biochemical studies of
the flavi- and alphavirus have revealed a new class of viral fusion
proteins (class II), that are significantly different from the class I
viral fusion proteins represented by influenza hemagglutinin (HA).
We are pursuing crystallographic studies of the class II viral
fusion proteins at their low-pH-induced fusion-active states.
Positions
|
|
1992-1993
|
Undergraduate Research
Assistant, Howard D. Dewald, Ohio University |
1994-1998
|
Graduate Research
Assistant, Don C. Wiley, Harvard University |
1998-1999
|
Postdoctoral Fellow, Don
C. Wiley, Harvard University |
1999-2001
|
Postdoctoral Fellow,
Florante A. Quiocho, Baylor College of Medicine
|
2002-2007
|
Assistant Professor,
Department of Biological Sciences, Purdue University
|
2007-present
|
Associate Professor,
Department of Biological Sciences, Purdue University
|
|
|
Honors
|
|
2003
|
Pew Scholar
|
Extramural Grants
|
